Target List
Insulin Signaling
AKT3, IGF1, IGF1R, IKBKB (IKKβ), INSR, IRS1, IRS2, MAP2K1, MAPK3 (ERK1), MAPK9 (JNK2), MTOR, PDE3B, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), PPARGC1A (PGC-1α), PTPN1 (PTP1B), RPS6KB1, SLC2A4 (GLUT4), SOCS3, SREBF1
Non-Insulin Dependent Diabetes Mellitus
ADIPOQ (ACRP30), HK2, IKBKB (IKKβ), INSR, IRS1, IRS2, MAPK3 (ERK1), MAPK9 (JNK2), MTOR, PDX1, PIK3CA (p110-alpha), PIK3R1 (p85-ALPHA), SLC2A4 (GLUT4), SOCS3, TNF
Adipokine Signaling
Adipokines
ADIPOQ (ACRP30), IL6, LEP (Leptin), NAMPT, RETN, SERPINE1 (PAI-1), TNF
Receptors & Transporters
ADIPOR1, ADIPOR2, CD36, LEPR, SLC2A4 (GLUT4), TNFRSF1A (TNFR1), TNFRSF1B
Signaling Downstream of Adipokines
AKT3, CHUK (IKKα), IKBKB (IKKβ), IRS1, IRS2, JAK2, MAPK9 (JNK2), MTOR, NFKBIA (IκBα, MAD3), PPARA, PPARGC1A (PGC-1α), RELA, SOCS3, STAT3
Innate Immunity
CASP1 (ICE), CHUK (IKKα), IKBKB (IKKβ), IRS1, IRS2, NLRP3, NFKBIA (IκBα, MAD3), PYCARD (TMS1, ASC), RELA, TLR4
Inflammation
ALOX5, CASP1 (ICE), CCL2 (MCP-1), CCR4, CCR5, CHUK (IKKα), CXCR4, IFNG, IKBKB (IKKβ), IL1B, IL23R, IL6, CXCL8 (IL8), LTA4H, NLRP3, OLR1, PYCARD (TMS1, ASC), RELA, TNF, TNFRSF1A (TNFR1), TNFRSF1B
Apoptosis
PPARG, SERPINE1 (PAI-1), TNF, CASP1 (ICE), IKBKB (IKKβ), IRS2, MAPK9 (JNK2), NFKBIA (IκBα, MAD3), NLRP3, PYCARD (TMS1, ASC), RELA, TNFRSF1A (TNFR1), JAK2, PIK3CA (p110-alpha), SOCS3, RPS6KB1, TNFRSF1B
Metabolic Pathways
Carbohydrate Metabolism
CS, HK2, PCK1, PDK2
Lipid Metabolism
ACACA, ACACB, ACSL1, ACSL4, APOE, CEBPA, CNBP, FABP4, FASN, LEPR, LIPE, LPL, PPARA, PPARG, PPARGC1A (PGC-1α), SCD, SREBF1, SREBF2
Metabolite Transport
APOE, CD36, FABP4, RBP4, SLC2A4 (GLUT4), SLC27A1, UCP1, VLDLR
Infiltrating Leukocyte Markers
Macrophages
CCR5, CXCR4, ADGRE1 (EMR1)
Th1 Cells
CCR5, CD3E, CXCR3, IL18R1
Th2 Cells
CCR4, CD3E, CRLF2 (TSLPR), IL1R1
Th17 Cells
CCR6, CD3E, IL23R