Serotonin Receptor Signaling
Serotonin is a monoamine neurotransmitter synthesized in the CNS. It is an important modulator of sleep, body temperature and metabolism. Guanosine triphosphate cyclohydrolase I (GCH1) catalyzes the production of Tetrahydrobiopterin (BH4), a required cofactor in the conversion of L-tryptophan to 5-hydroxytryptophan which is then converted to serotonin. Serotonin is released at the synapse of the presynaptic neuron where it binds to its receptor on the postsynaptic neuron....
Pathway Summary
Serotonin is a monoamine neurotransmitter synthesized in the CNS. It is an important modulator of sleep, body temperature and metabolism. Guanosine triphosphate cyclohydrolase I (GCH1) catalyzes the production of Tetrahydrobiopterin (BH4), a required cofactor in the conversion of L-tryptophan to 5-hydroxytryptophan which is then converted to serotonin. Serotonin is released at the synapse of the presynaptic neuron where it binds to its receptor on the postsynaptic neuron.The 5-hydroxytryptamine (HT) receptors are serotonin receptors. All members of this family are GPCRs with the exception of 5-HT3 receptor which is a ligand gated ion channel. Serotonin acts via its receptor mainly to activate or inhibit adenylate cyclase thereby regulating vasoconstriction, opening/closing of channels and platelet aggregation.Serotonin is targeted for inactivation via its transporter SERT. Monoamine oxidase catalyzes the oxidative deamination of serotonin (5-HT) to 5-hydroxyindoleacetic acid which is translocated to cerebrospinal fluid.
Serotonin Receptor Signaling Genes list
Explore Genes related to Serotonin Receptor Signaling
AANATaralkylamine N-acetyltransferase ABHD3abhydrolase domain containing 3, phospholipase ACAT1acetyl-CoA acetyltransferase 1 ADCY1adenylate cyclase 1 ADCY10adenylate cyclase 10 ADCY2adenylate cyclase 2 ADCY3adenylate cyclase 3 ADCY4adenylate cyclase 4 ADCY5adenylate cyclase 5 ADCY6adenylate cyclase 6 ADCY7adenylate cyclase 7 ADCY8adenylate cyclase 8 ADCY9adenylate cyclase 9 ADIPOQadiponectin, C1Q and collagen domain containing ADRA1Aadrenoceptor alpha 1A ADRA1Badrenoceptor alpha 1B ADRA1Dadrenoceptor alpha 1D ADRA2Aadrenoceptor alpha 2A ADRA2Badrenoceptor alpha 2B ADRA2Cadrenoceptor alpha 2C ADRB1adrenoceptor beta 1 ADRB2adrenoceptor beta 2 ADRB3adrenoceptor beta 3 AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 ARAFA-Raf proto-oncogene, serine/threonine kinase ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1 ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2 ARRB1arrestin beta 1 ARRB2arrestin beta 2 ASMTacetylserotonin O-methyltransferase ATF2activating transcription factor 2 ATF4activating transcription factor 4 BCL2BCL2 apoptosis regulator BDNFbrain derived neurotrophic factor BLKBLK proto-oncogene, Src family tyrosine kinase BRAFB-Raf proto-oncogene, serine/threonine kinase BST1bone marrow stromal cell antigen 1 CACNA1Acalcium voltage-gated channel subunit alpha1 A CACNA1Bcalcium voltage-gated channel subunit alpha1 B CACNA1Ccalcium voltage-gated channel subunit alpha1 C CACNA1Dcalcium voltage-gated channel subunit alpha1 D CACNA1Ecalcium voltage-gated channel subunit alpha1 E CACNA1Fcalcium voltage-gated channel subunit alpha1 F CACNA1Gcalcium voltage-gated channel subunit alpha1 G CACNA1Hcalcium voltage-gated channel subunit alpha1 H CACNA1Icalcium voltage-gated channel subunit alpha1 I CACNA1Scalcium voltage-gated channel subunit alpha1 S CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 CACNA2D2calcium voltage-gated channel auxiliary subunit alpha2delta 2 CACNA2D3calcium voltage-gated channel auxiliary subunit alpha2delta 3 CACNA2D4calcium voltage-gated channel auxiliary subunit alpha2delta 4 CACNB1calcium voltage-gated channel auxiliary subunit beta 1 CACNB2calcium voltage-gated channel auxiliary subunit beta 2 CACNB3calcium voltage-gated channel auxiliary subunit beta 3 CACNB4calcium voltage-gated channel auxiliary subunit beta 4 CACNG1calcium voltage-gated channel auxiliary subunit gamma 1 CACNG2calcium voltage-gated channel auxiliary subunit gamma 2 CACNG3calcium voltage-gated channel auxiliary subunit gamma 3 CACNG4calcium voltage-gated channel auxiliary subunit gamma 4 CACNG5calcium voltage-gated channel auxiliary subunit gamma 5 CACNG6calcium voltage-gated channel auxiliary subunit gamma 6 CACNG7calcium voltage-gated channel auxiliary subunit gamma 7 CACNG8calcium voltage-gated channel auxiliary subunit gamma 8 CALML5calmodulin like 5 CAMK2Acalcium/calmodulin dependent protein kinase II alpha CAMK2Bcalcium/calmodulin dependent protein kinase II beta CAMK2Dcalcium/calmodulin dependent protein kinase II delta CAMK2Gcalcium/calmodulin dependent protein kinase II gamma CAMPcathelicidin antimicrobial peptide CASP3caspase 3 CAV1caveolin 1 CAV2caveolin 2 CAV3caveolin 3 CCNE1cyclin E1 CCNE2cyclin E2 CCR7C-C motif chemokine receptor 7 CD38CD38 molecule CD44CD44 molecule (Indian blood group) CDC42cell division cycle 42 CDH1cadherin 1 CDK2cyclin dependent kinase 2 CDK5cyclin dependent kinase 5 COPS5COP9 signalosome subunit 5 CPEcarboxypeptidase E CREB1cAMP responsive element binding protein 1 CREB3cAMP responsive element binding protein 3 CREB3L1cAMP responsive element binding protein 3 like 1 CREB3L2cAMP responsive element binding protein 3 like 2 CREB3L3cAMP responsive element binding protein 3 like 3 CREB3L4cAMP responsive element binding protein 3 like 4 CREB5cAMP responsive element binding protein 5 CREBBPCREB binding protein CXCL8C-X-C motif chemokine ligand 8 DDCdopa decarboxylase DIRAS3DIRAS family GTPase 3 EDN1endothelin 1 EIF4EBP1eukaryotic translation initiation factor 4E binding protein 1 ERASES cell expressed Ras F13A1coagulation factor XIII A chain F13Bcoagulation factor XIII B chain FBP1fructose-bisphosphatase 1 FBP2fructose-bisphosphatase 2 FFAR2free fatty acid receptor 2 FFAR3free fatty acid receptor 3 FGAfibrinogen alpha chain FGBfibrinogen beta chain FGGfibrinogen gamma chain FGRFGR proto-oncogene, Src family tyrosine kinase FNBP1formin binding protein 1 FOXO1forkhead box O1 FOXO3forkhead box O3 FRKfyn related Src family tyrosine kinase FYNFYN proto-oncogene, Src family tyrosine kinase G6PC1glucose-6-phosphatase catalytic subunit 1 G6PC2glucose-6-phosphatase catalytic subunit 2 G6PC3glucose-6-phosphatase catalytic subunit 3 GAP43growth associated protein 43 GCH1GTP cyclohydrolase 1 GNA11G protein subunit alpha 11 GNA12G protein subunit alpha 12 GNA13G protein subunit alpha 13 GNA14G protein subunit alpha 14 GNA15G protein subunit alpha 15 GNAI1G protein subunit alpha i1 GNAI2G protein subunit alpha i2 GNAI3G protein subunit alpha i3 GNALG protein subunit alpha L GNAO1G protein subunit alpha o1 GNAQG protein subunit alpha q GNB1G protein subunit beta 1 GNB1LG protein subunit beta 1 like GNB2G protein subunit beta 2 GNB3G protein subunit beta 3 GNB4G protein subunit beta 4 GNB5G protein subunit beta 5 GNG10G protein subunit gamma 10 GNG11G protein subunit gamma 11 GNG12G protein subunit gamma 12 GNG13G protein subunit gamma 13 GNG2G protein subunit gamma 2 GNG3G protein subunit gamma 3 GNG4G protein subunit gamma 4 GNG5G protein subunit gamma 5 GNG7G protein subunit gamma 7 GPBAR1G protein-coupled bile acid receptor 1 GPLD1glycosylphosphatidylinositol specific phospholipase D1 GPR37G protein-coupled receptor 37 GSK3Bglycogen synthase kinase 3 beta GUCY1A1guanylate cyclase 1 soluble subunit alpha 1 GUCY1B1guanylate cyclase 1 soluble subunit beta 1 H3-4H3.4 histone H3C14H3 clustered histone 14 H3C3H3 clustered histone 3 HCKHCK proto-oncogene, Src family tyrosine kinase HIF1Ahypoxia inducible factor 1 subunit alpha HMOX1heme oxygenase 1 HRASHRas proto-oncogene, GTPase HTR1A5-hydroxytryptamine receptor 1A HTR1B5-hydroxytryptamine receptor 1B HTR1D5-hydroxytryptamine receptor 1D HTR1E5-hydroxytryptamine receptor 1E HTR2A5-hydroxytryptamine receptor 2A HTR2B5-hydroxytryptamine receptor 2B HTR2C5-hydroxytryptamine receptor 2C HTR3A5-hydroxytryptamine receptor 3A HTR3B5-hydroxytryptamine receptor 3B HTR3C5-hydroxytryptamine receptor 3C HTR3D5-hydroxytryptamine receptor 3D HTR3E5-hydroxytryptamine receptor 3E HTR45-hydroxytryptamine receptor 4 HTR5A5-hydroxytryptamine receptor 5A HTR65-hydroxytryptamine receptor 6 HTR75-hydroxytryptamine receptor 7 IL12Ainterleukin 12A IL12Binterleukin 12B IL1Binterleukin 1 beta IL1RL1interleukin 1 receptor like 1 IL2interleukin 2 IL33interleukin 33 IL4I1interleukin 4 induced 1 IL6interleukin 6 ITGA2Bintegrin subunit alpha 2b ITGB1integrin subunit beta 1 ITGB3integrin subunit beta 3 JAK2Janus kinase 2 JUNJun proto-oncogene, AP-1 transcription factor subunit KALRNkalirin RhoGEF kinase KCNA5potassium voltage-gated channel subfamily A member 5 KCNH2potassium voltage-gated channel subfamily H member 2 KCNJ3potassium inwardly rectifying channel subfamily J member 3 KCNJ5potassium inwardly rectifying channel subfamily J member 5 KCNJ6potassium inwardly rectifying channel subfamily J member 6 KCNJ9potassium inwardly rectifying channel subfamily J member 9 KCNN1potassium calcium-activated channel subfamily N member 1 KCNN2potassium calcium-activated channel subfamily N member 2 KCNN3potassium calcium-activated channel subfamily N member 3 KCNN4potassium calcium-activated channel subfamily N member 4 KCNQ2potassium voltage-gated channel subfamily Q member 2 KCNQ3potassium voltage-gated channel subfamily Q member 3 KRASKRAS proto-oncogene, GTPase LCATlecithin-cholesterol acyltransferase LCKLCK proto-oncogene, Src family tyrosine kinase LEPleptin LIPElipase E, hormone sensitive type LYNLYN proto-oncogene, Src family tyrosine kinase MAOAmonoamine oxidase A MAOBmonoamine oxidase B MAP1LC3Bmicrotubule associated protein 1 light chain 3 beta MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAP2K3mitogen-activated protein kinase kinase 3 MAP2K4mitogen-activated protein kinase kinase 4 MAP2K5mitogen-activated protein kinase kinase 5 MAP2K6mitogen-activated protein kinase kinase 6 MAP2K7mitogen-activated protein kinase kinase 7 MAP3K5mitogen-activated protein kinase kinase kinase 5 MAPK1mitogen-activated protein kinase 1 MAPK11mitogen-activated protein kinase 11 MAPK12mitogen-activated protein kinase 12 MAPK13mitogen-activated protein kinase 13 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MAPTmicrotubule associated protein tau MMP2matrix metallopeptidase 2 MMP9matrix metallopeptidase 9 MPDZmultiple PDZ domain crumbs cell polarity complex component MPRIPmyosin phosphatase Rho interacting protein MRASmuscle RAS oncogene homolog MTORmechanistic target of rapamycin kinase MYCMYC proto-oncogene, bHLH transcription factor MYL2myosin light chain 2 MYLKmyosin light chain kinase MYLK2myosin light chain kinase 2 MYLK3myosin light chain kinase 3 NAPEPLDN-acyl phosphatidylethanolamine phospholipase D NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NFKBIANFKB inhibitor alpha NOTUMnotum, palmitoleoyl-protein carboxylesterase NPPBnatriuretic peptide B NRASNRAS proto-oncogene, GTPase OCLNoccludin ORAI1ORAI calcium release-activated calcium modulator 1 ORAI2ORAI calcium release-activated calcium modulator 2 ORAI3ORAI calcium release-activated calcium modulator 3 PAK1p21 (RAC1) activated kinase 1 PAK2p21 (RAC1) activated kinase 2 PAK3p21 (RAC1) activated kinase 3 PAK4p21 (RAC1) activated kinase 4 PAK5p21 (RAC1) activated kinase 5 PAK6p21 (RAC1) activated kinase 6 PCpyruvate carboxylase PCBD1pterin-4 alpha-carbinolamine dehydratase 1 PDIA3protein disulfide isomerase family A member 3 PDK1pyruvate dehydrogenase kinase 1 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PLA2G10phospholipase A2 group X PLA2G12Aphospholipase A2 group XIIA PLA2G12Bphospholipase A2 group XIIB PLA2G1Bphospholipase A2 group IB PLA2G2Aphospholipase A2 group IIA PLA2G2Cphospholipase A2 group IIC PLA2G2Dphospholipase A2 group IID PLA2G2Ephospholipase A2 group IIE PLA2G2Fphospholipase A2 group IIF PLA2G3phospholipase A2 group III PLA2G4Aphospholipase A2 group IVA PLA2G4Bphospholipase A2 group IVB PLA2G4Cphospholipase A2 group IVC PLA2G4Dphospholipase A2 group IVD PLA2G4Ephospholipase A2 group IVE PLA2G4Fphospholipase A2 group IVF PLA2G5phospholipase A2 group V PLA2G6phospholipase A2 group VI PLA2G7phospholipase A2 group VII PLA2R1phospholipase A2 receptor 1 PLAAT1phospholipase A and acyltransferase 1 PLAAT2phospholipase A and acyltransferase 2 PLAAT3phospholipase A and acyltransferase 3 PLAAT4phospholipase A and acyltransferase 4 PLAAT5phospholipase A and acyltransferase 5 PLAURplasminogen activator, urokinase receptor PLB1phospholipase B1 PLCB1phospholipase C beta 1 PLCB2phospholipase C beta 2 PLCB3phospholipase C beta 3 PLCB4phospholipase C beta 4 PLCD1phospholipase C delta 1 PLCD3phospholipase C delta 3 PLCD4phospholipase C delta 4 PLCE1phospholipase C epsilon 1 PLCG1phospholipase C gamma 1 PLCG2phospholipase C gamma 2 PLCH1phospholipase C eta 1 PLCH2phospholipase C eta 2 PLCL1phospholipase C like 1 (inactive) PLCL2phospholipase C like 2 PLCZ1phospholipase C zeta 1 PLD1phospholipase D1 PLD2phospholipase D2 PLD3phospholipase D family member 3 PLD4phospholipase D family member 4 PLD5phospholipase D family member 5 PLD6phospholipase D family member 6 PLIN1perilipin 1 PLNphospholamban PNPLA2patatin like phospholipase domain containing 2 PNPLA3patatin like phospholipase domain containing 3 PNPLA4patatin like phospholipase domain containing 4 PNPLA8patatin like phospholipase domain containing 8 PPARGC1APPARG coactivator 1 alpha PPP1CBprotein phosphatase 1 catalytic subunit beta PPP1R12Aprotein phosphatase 1 regulatory subunit 12A PPP1R12Bprotein phosphatase 1 regulatory subunit 12B PRDX6peroxiredoxin 6 PRKACAprotein kinase cAMP-activated catalytic subunit alpha PRKACBprotein kinase cAMP-activated catalytic subunit beta PRKACGprotein kinase cAMP-activated catalytic subunit gamma PRKAG1protein kinase AMP-activated non-catalytic subunit gamma 1 PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta PRKAR2Aprotein kinase cAMP-dependent type II regulatory subunit alpha PRKAR2Bprotein kinase cAMP-dependent type II regulatory subunit beta PRKCAprotein kinase C alpha PRKCBprotein kinase C beta PRKCDprotein kinase C delta PRKCEprotein kinase C epsilon PRKCGprotein kinase C gamma PRKCHprotein kinase C eta PRKCIprotein kinase C iota PRKCQprotein kinase C theta PRKCZprotein kinase C zeta PRKD1protein kinase D1 PRKD3protein kinase D3 PSD4pleckstrin and Sec7 domain containing 4 PTGS1prostaglandin-endoperoxide synthase 1 PTGS2prostaglandin-endoperoxide synthase 2 PTS6-pyruvoyltetrahydropterin synthase QDPRquinoid dihydropteridine reductase RAB27ARAB27A, member RAS oncogene family RAB3ARAB3A, member RAS oncogene family RAB4ARAB4A, member RAS oncogene family RAB4BRAB4B, member RAS oncogene family RAC1Rac family small GTPase 1 RAC2Rac family small GTPase 2 RAC3Rac family small GTPase 3 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RAPGEF3Rap guanine nucleotide exchange factor 3 RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RASGRF1Ras protein specific guanine nucleotide releasing factor 1 RB1RB transcriptional corepressor 1 RBL1RB transcriptional corepressor like 1 RBL2RB transcriptional corepressor like 2 RHOAras homolog family member A RHOBras homolog family member B RHOBTB1Rho related BTB domain containing 1 RHOBTB2Rho related BTB domain containing 2 RHOCras homolog family member C RHODras homolog family member D RHOFras homolog family member F, filopodia associated RHOGras homolog family member G RHOHras homolog family member H RHOJras homolog family member J RHOQras homolog family member Q RHOT1ras homolog family member T1 RHOT2ras homolog family member T2 RHOUras homolog family member U RHOVras homolog family member V RND1Rho family GTPase 1 RND2Rho family GTPase 2 RND3Rho family GTPase 3 ROCK1Rho associated coiled-coil containing protein kinase 1 ROCK2Rho associated coiled-coil containing protein kinase 2 RPS6KA3ribosomal protein S6 kinase A3 RPS6KB1ribosomal protein S6 kinase B1 RPS6KB2ribosomal protein S6 kinase B2 RRASRAS related RRAS2RAS related 2 RYR1ryanodine receptor 1 RYR2ryanodine receptor 2 RYR3ryanodine receptor 3 SHANK3SH3 and multiple ankyrin repeat domains 3 SLC18A1solute carrier family 18 member A1 SLC18A2solute carrier family 18 member A2 SLC18A3solute carrier family 18 member A3 SLC6A4solute carrier family 6 member 4 SLC9A3solute carrier family 9 member A3 SLC9A5solute carrier family 9 member A5 SMOXspermine oxidase SNAI1snail family transcriptional repressor 1 SP7Sp7 transcription factor SPRsepiapterin reductase SQSTM1sequestosome 1 SRCSRC proto-oncogene, non-receptor tyrosine kinase SRFserum response factor STAT3signal transducer and activator of transcription 3 STIM1stromal interaction molecule 1 STIM2stromal interaction molecule 2 TEAD1TEA domain transcription factor 1 TGFB1transforming growth factor beta 1 TGFB2transforming growth factor beta 2 TGFB3transforming growth factor beta 3 TGM1transglutaminase 1 TGM2transglutaminase 2 TGM3transglutaminase 3 TGM4transglutaminase 4 TGM5transglutaminase 5 TGM6transglutaminase 6 TGM7transglutaminase 7 TNFtumor necrosis factor TNNI1troponin I1, slow skeletal type TNNI2troponin I2, fast skeletal type TNNI3troponin I3, cardiac type TP63tumor protein p63 TPH1tryptophan hydroxylase 1 TPH2tryptophan hydroxylase 2 TRPA1transient receptor potential cation channel subfamily A member 1 TRPC1transient receptor potential cation channel subfamily C member 1 TRPC2transient receptor potential cation channel subfamily C member 2 (pseudogene) TRPC3transient receptor potential cation channel subfamily C member 3 TRPC4transient receptor potential cation channel subfamily C member 4 TRPC5transient receptor potential cation channel subfamily C member 5 TRPC6transient receptor potential cation channel subfamily C member 6 TRPC7transient receptor potential cation channel subfamily C member 7 TRPM8transient receptor potential cation channel subfamily M member 8 TRPV6transient receptor potential cation channel subfamily V member 6 TTNtitin VWFvon Willebrand factor YAP1Yes1 associated transcriptional regulator YES1YES proto-oncogene 1, Src family tyrosine kinase